Although Archaea inhabit the human body and possess some characteristics of pathogens, there is a notable lack of pathogenic archaeal species identified to date. We hypothesize that the scarcity of disease‐causing Archaea is due, in part, to mutually‐exclusive phage and virus populations infecting Bacteria and Archaea, coupled with an association of bacterial virulence factors with phages or mobile elements. The ability of bacterial phages to infect Bacteria and then use them as a vehicle to infect eukaryotes may be difficult for (...) archaeal viruses to evolve independently. Differences in extracellular structures between Bacteria and Archaea would make adsorption of bacterial phage particles onto Archaea (i.e. horizontal transfer of virulence) exceedingly hard. If phage and virus populations are indeed exclusive to their respective host Domains, this has important implications for both the evolution of pathogens and approaches to infectious disease control. (shrink)

Background Genuine uncertainty on superiority of one intervention over the other is called equipoise. Physician-investigators in randomized controlled trials need equipoise at least in studies with more than minimal risks. Ideally, this equipoise is also present in patient-participants. In pediatrics, data on equipoise are lacking. We hypothesize that 1) lack of equipoise at enrolment among parents may reduce recruitment; 2) lack of equipoise during participation may reduce retention in patients assigned to a less favoured treatment-strategy. Methods We compared preferences of (...) parents/patients at enrolment, documented by a questionnaire, with preferences developed during follow-up by an interview-study to investigate equipoise of child-participants and parents in the BeSt-for-Kids-study. This trial in new-onset Juvenile Idiopathic Arthritis-patients consists of three strategies. One strategy comprises initial treatment with a biological disease-modifying-antirheumatic-drug, currently not standard-of-care. Semi-structured interviews were conducted with 23 parents and 7 patients, median 11 months after enrolment. Results Initially most parents and children were not in equipoise. Parents/patients who refused participation, regularly declined due to specific preferences. Many participating families preferred the biological-first-strategy. They participated to have a chance for this initial treatment, and would even consider stopping trial-participation when not randomized for it. Their conviction of superiority of the biological-first strategy was based on knowledge from internet and close relations. According to four parents, the physician-investigator preferred the biological-first-strategy, but the majority stated that she had no preferred strategy. In phase 2, preferences tended to change to the treatment actually received. Conclusions Lack of equipoise during enrolment did not reduce study recruitment, mainly due to the fact that preferred treatment was only available within the study. Still, when developing a trial it is important to evaluate whether the physicians’ research question is in line with preferences of the patient-group. By exploring so-called ‘informed patient-group’-equipoise, successful recruitment may be enhanced and bias avoided. In our study, lack of equipoise during trial-participation did not reduce retention in those assigned to a less favoured option. We observed a change for preference towards treatment actually received, possibly explained by comparable outcomes in all three arms. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Books reviewed in this article: The Anchor Bible Dictionary. Edited by David Noel Freedman with Gary A. Herion, David F. Graf, John David Pleins. The Gospel of Matthew. By Daniel J. Harrington. Paul: An Introduction to his Thought. By C. K. Barrett. A Radical Jew: Paul and the Politics of Identiy. By Daniel Boyarin. New Testament Theology. By G. B. Caird, completed and edited by L. D. Hurst. The Fatherhood of God from Origen to Athanasius. By Peter Widdicombe. Dieu et (...) le Christ selon Grégoire de Nysse. By Bernard Pottier. Eucharistic Presence: A Study in the Theology of Disclosure. By Robert Sokolowski. Theological Hermeneutics: Development and Significance. By Werner Jeanrond. Theologie aus Efahrung der Gnade. Annäherungen an Karl Rahner: Edited by Mariano Delgado and Mathias‐Lutz Bachmann. Bernhard Welte's Fundamental Theological Approach to Christology.. By Anthony J. Godzieba. Sacred Identity: Exploring a Theology of the Person. By Jane Kopas. A Salvation Audit. By Colin Grant. Medical Ezhics: Sources Of Catholic Teachings, Second Edition. Edited by Kevin O'Rourke and Philip Boyle. Mission and Conversion: Proselytizing in the Religious History of the Roman Empire. By Martin Goodman. Literacy and Power in the Ancient World. Edited by Alan K. Bowman and Greg Woolf. St Cyril of Alexandria: The Christological Controversy. Its History, Theology and Texts. By John A. McGuckin. Ambrose of Milan: Church and Court in a Christian Capital. By Neil B. McLynn. Basil of Cuesareu. By Philip Rousseau. Augustine. By Mary T. Clark. Irenaeus. By Dennis Minns. Divine Heiress: The Virgin Mary and the Creation of Christian Constantinople. By Vasiliki Limberis. The Irish Tradition in Old English Literature. By Charles D. Wright. Relics, Apocalypse and the Deceils of History: Ademar of Chabannes, 989–1034. By Richard Landes. Huguccio: The Life, Works, and Thought of a Twelfth‐Centuy Jurist. By Wolfgang P. Müller. The Presence of God: A History of Western Christian Mysticism, Volume II: The Growth of Mysticism. By Bernard McGinn. Preaching the Crusades: Mendicant Friars and the Cross in the Thirteenth Century. By Christoph T. Maier. Mary Ward: A World in Contemplation. By Henriette Peters. The Letters of Teilhard de Chardin and Lucile Swan. Edited by Thomas M. King and Mary Wood Gilbert. Pseudo‐Marry: By John Donne. Edited, with an Introduction and Commentary, by Anthony Raspa. Donne and the Politics of Conscience in Early Modern England. By M. L. Brown. The Caroline Captivity of the Church: Charles 1 and the Remoulding of Anglicanism. By Julian Davies. Érudition et religion aux XVIIe et XVIIIe siécles. By Bruno Neveu. Cardinal Lavigerie: Churchman, Prophet and Missionary. By François Renault. Dom Columba Marmion: A Biography By Mark Tierney. Christian Mission in the Twentieth Century. By Timothy Yates. Religion in Africa: Experience and Expression. Edited by Thomas D. Blakely, Walter E. A. van Beek and Dennis Thomson. (shrink)

Books Reviewed in this Article: Theological Investigations, Vol. XVIII: God and Revelation. By Karl Rahner. Pp.vi, 304, London, Darton, Longman and Todd, 1984, £18.50. Theological Investigations, Volume XIX: Faith and Ministry. By Karl Rahner. Pp.vi, 282, London, Darton, Longman & Todd, 1984, £18.50. Theological Investigations: Volume XX: Concern for the Church. By Karl Rahner. Pp.vi, 191, London, Darton, Longman & Todd, 1981, £14.50. Concise Theological Dictionary. Edited by Karl Rahner and Herbert Vorgrimler. Pp.541, London, Burns & Oates, 1983, £12.50. A (...) New Dictionary of Christian Theology. Edited by Alan Richardson and John Bowden. Pp.xvii, 614, London, SCM Press, 1983, £19.50. The God of Forgiveness and Healing in the Theology of Karl Rahner. By J.N. King, Pp.93, Washington, University Press of America, 1982, $17.50, $6.75. In Search of Humanity, A Theological and Philosophical Approach. By John Macquarrie. Pp.vii, 280, London, SCM Press, 1982, £8.50. Faith and the Mystery of God. By Maurice Wiles. Pp.viii, 146, London, SCM Press, 1982, £4.50. Trinity and Temporality: The Christian Doctrine of God in the Light of Process Theology and the Theology of Hope. By John J. O'Donnell. Pp.xii, 215, Oxford University Press, 1983, £15.00. The Cosmic Christ in Origen and Teilhard de Chardin: A comparative Study. By James A. Lyons and edited by Maurice Wiles. Pp.xii, 236, Oxford University Press, 1982, £13.50. Grounded in Love: Sacramental Theology in an Ecumenical Perspective. By Frans Josef van Beeck. Pp.x, 151, Washington, University Press of America, 1982, $19.50, $9.25. Justification: The Author's First Book reissued with a New Introductory Chapter and the Original Response of Karl Barth. By Hans Küng. Pp.xlvi, 332, London, Burns and Oates, 1982, no price given. Reality and Evangelical Theology. By T.F. Torrance. Pp.174, Philadelphia, Westminster Press, 1982, $8.95. The Quest for the Historical Israel: Reconstructing Israel's Early History. By George W. Ramsey. Pp.xiv, 193, London, SCM Press, 1982, £5.50. Cantico del Cantici: Interpretatio Ludica. By Enrica Salvaneschi. Pp.140. Genoa, II Melangolo, 1982, 15, 000 Lire. Love Lyrics from the Bible: A Translation and Literary Study of the Song of Songs. By Marcia Falk. Pp.142, Sheffield, Almond Press, 1982, £14.95, £5.95. Old Testament Wisdom: An Introduction. By James L. Crenshaw. Pp.286, London, SCM Press, 1982, £5.95. The Sciences and Theology. Edited by A.R. Peacocke. Pp.xviii, 309, Stocksfield, Oriel Press, 1982, £14.00. Vision and Character: A Christian Educator's Alternative to Kohlberg. By C.R. Dykstra. Pp.viii, 160, Leominster, Fowler Wright Books, 1981, £4.45. Aristotle's Eudemian Ethics, Books I, II & III. Translated with a commentary by Michael Woods. Pp.xii, 234, Oxford, Clarendon Press: Oxford University Press, 1982, £11.50. Kant's Theory of Mind: An Analysis of the Paralogisms of Pure Reason. By Karl Ameriks. Pp.ix, 314, Oxford, Clarendon Press, 1982, £15.00. Heidegger's‘Being and Time’and the Possibility of Political Philosophy. By Mark Blitz. Pp.260, Ithaca, Cornell University Press, 1981, £13.75. Symbol as Sense: New Approaches to the Analysis of Meaning. Edited by Mary Le Cron Foster and Stanley H. Brandes. Pp.xvi, 416, New York, Academic Press, 1980, £19.60. The God Within. By Harry R. Klocker. Pp.x, 147, Washington, University Press of America, 1982, $19.00, $9.25. The Philosophical Frontiers of Christian Theology: Essays Presented to D.M. MacKinnon. Edited by Brian Hebblethwaite and Stewart Sutherland. Pp.ix, 252, Cambridge University Press, 1982, £17.50. Jews, Pagans and Christians in Conflict. By David Rokeah. Pp.232, Jerusalem, The Magnes Press, The Hebrew University, Leiden; E.J. Brill, 1982, 94 gld. Religion, Law, and the Growth of Constitutional Thought 1150–1650. By Brian Tierney. Pp.xi, 114, Cambridge University Press, 1982, £12.50. St John of the Cross: The Life and Thought of a Christian Mystic. By Alain Cugno. Pp.vi, 153, London, Burns & Oates, 1982, £6.95. Meister Eckhart: The Essential Sermons, Commentaries, Treatises and Defense. Translated by Edmund Colledge and Bernard McGinn. Pp.xviii, 360, London, SPCK, 1981, £8.50. Francisco de Osuna: the Third Spiritual Alphabet. Translated by May E. Giles. Pp.xvi, 624, London, SPCK, 1981, £12.50. Rome and the Anglicans. Edited with a Postscript by Wolfgang Haase. Pp.301, Berlin, Walter de Gruyter, 1982, 138 DM. The Westminster Confession in the Church today: Papers Prepared for the Church of Scotland Panel on Doctrine. Edited by Alasdair I.C. Heron. Pp.vii, 154, Edinburgh, Saint Andrew Press, 1982, £4.00. Essaying Montaigne: A Study of the Renaissance Institution of Writing and Reading. By John O'Neill, Pp.ix, 244, London, Routledge and Kegan Paul, 1982, £12.50. Rousseau after 200 years: Proceedings of the Cambridge Bicentennial Colloquium. Edited by R.A. Leigh. Pp.xv, 299, Cambridge University Press, 1982, £30.00 An American Experience of God: The Spirituality of Isaac Hecker. By John Farina. Pp.xii, 217, New York, Paulist Press, 1981, $11.95. Hecker Studies: Essays on the Thought of Isaac Hecker. Edited by John Farina. Pp.vii, 243, New York, Paulist Press, 1983, $6.95. (shrink)

Desde la antigüedad hasta hoy, la tradición vitruviana ha dominado los modos en que se ha entendido el oficio de la arquitectura y la figura del arquitecto en Occidente. Esta tradición hace de la arquitectura una práctica necesariamente relacionada con la edificación. Sin embargo, en los tiempos en que Vitruvio escribía su De Architectura, diferentes nociones sobre el oficio permeaban tanto en escritos dramáticos y filosóficos como en el sentido común de la época. En Cicerón y Eurípides, pero sobre todo (...) en Plauto, encontramos arquitecturas cuyos objetivos se alejaban del arte y se acercaban a la política, y arquitectos con habilidades que tenían menos que ver con la técnica, y más con la prudencia. Con ayuda del pensamiento aristotélico, veremos que estas figuras no eran meros caprichos dramatúrgicos ni moralistas, sino que poseían un fundamento epistemológico y práctico, que encontraba en la arquitectura un modo de pen- sar y de actuar más allá de la proyección y construcción de edificios. (shrink)

Seit über hundert Jahren wartet eine interessierte Öffentlichkeit auf eine umfassende, kritische, kommentierte Edition der Briefe Wilhelm von Humboldts. Die lange Reihe prominenter Akteure der Goethe-Zeit (bzw. der Napoleonischen Ära), die zu den Briefpartnern dieses Staatsmannes, Bildungsreformers und Sprachforschers zählen, sowie die Vielfalt der Themen – neben den bereits genannten sind dies vor allem Philosophie, Literatur, Philologie, bildende Kunst, Politik, diplomatische Korrespondenz, Geschichte – und nicht zuletzt die literarischen Qualitäten der Brieftexte selbst machen dieses umfangreiche Briefcorpus zu einem der bedeutendsten (...) der Epoche: ein Zeitgemälde auf höchstem Niveau. Die Ausgabe wird in drei Abteilungen erscheinen: I. Jugendbriefe, Brautzeit, erste Ehejahre (1781–1802) II. Amtszeit (1802–1819) III. Altersmuße (1820–1835). Die I. Abteilung wird fünf Bände umfassen. Band 1 beginnt mit Briefen des 13-jährigen Knaben; erster Schwerpunkt ist die Reihe schwärmerischer Briefe an Henriette Herz und weitere Mitglieder der „Verbindung“, einer Vereinigung zur gegenseitigen moralischen Vervollkommnung, die Humboldt bis zur Verlobung mit Karoline von Dacheröden intensiv beschäftigte; danach stehen die Briefe an die Braut im Vordergrund. Außerdem spielen die Briefe an Georg Forster und Friedrich Heinrich Jacobi eine wichtige Rolle; auch die später umfangreiche Korrespondenz mit Carl Gustaf von Brinkman beginnt bereits in dieser Periode. Mit der Eheschließung im Juni 1791 wird der Band abgeschlossen. Der Band enthält 198 Briefe, davon 21 bisher ungedruckte. (shrink)

A scholarly edition of The Clarendon Edition of the Works of John Locke: Correspondence: Letters 849-1241 by E. S. de Beer. The edition presents an authoritative text, together with an introduction, commentary notes, and scholarly apparatus.

In the _World Library of Educationalists_, international experts themselves compile career-long collections of what they judge to be their finest pieces – extracts from books, key articles, salient research findings, major theoretical and practical contributions – so the world can read them in a single manageable volume, allowing readers to follow the themes of their work and see how it contributes to the development of the field. Mary James has researched and written on a range of educational subjects which encompass (...) curriculum, pedagogy and assessment in schools, and implications for teachers´ professional development, school leadership and policy frameworks. She has written many books and journals on assessment, particularly assessment for learning and is an expert on teacher learning, curriculum, leadership for learning and educational policy. Starting with a specially written introduction in which Mary gives an overview of her career and contextualises her selection, the chapters are divided into three parts: Educational Assessment and Learning Educational Evaluation and Curriculum Development Educational Research and the Improvement of Practice Through this book, readers can follow the different strands that Mary James has researched and written about over the last three decades, and clearly see her important contribution to the field of education. (shrink)

In an essay entitled “Freedom and Personality” I have contended that “intelligence is a principle of indetermination within us.” As I find that my argument, though to myself it appears incontrovertible, has not produced conviction in some quarters where I had hoped it might be effective, I can only suppose that, presumably by my own fault, it was not stated as clearly as it should have been. This must be my excuse for returning to the subject; in doing so I (...) shall try to be, to the best of my power, at once brief and lucid. (shrink)

In his article on “The Nature and the Status of the Study of Politics” 1 Professor White raises, whether explicitly or by implication, some of the most important and, probably permanent problems of the subject. The solutions that he attempts to provide seem to me, however, to be less satisfying than might be expected.

This paper is a discussion and a criticism of the account of the Philosophy of Resemblances which appears in the first chapter of Professor H. H. Price's Thinking and Experience.

In 394 Agesilaus, treading in the footsteps of Xerxes, came from Asia by way of Thrace and Macedon into Thessaly, threw off the attacks of the Thessalian cavalry, proceeded without further trouble into Boeotia, and met the enemy at Coronea, where a great battle was fought. The question ought to have been asked before now, why was he not held up at Thermopylae?

In the middle of the third book of his Histories, Tacitus records some movements in the western provinces occasioned by the events of 69. The troops in Britain, he says, were partial to Vespasian, who had served there with distinction in the reign of Claudius, and a party was formed in his interest.